Male and Female Animals Respond Differently to High-Fat Diet and Regular Exercise Training in a Mouse Model of Hyperlipidemia

Inappropriate nutrition and a sedentary lifestyle can lead to obesity, one of the most common risk factors for several chronic diseases. Although regular physical exercise is an efficient approach improve cardiometabolic health, exact cellular processes are still not fully understood. We aimed analyze morphological, gene expression, lipidomic patterns in liver adipose tissues response exercise. Healthy (wild type on normal diet) hyperlipidemic, high-fat diet-fed (HFD-fed) apolipoprotein B-100 (APOB-100)-overexpressing mice were trained by treadmill running 7 months. The serum concentrations triglyceride tumor necrosis factor ? (TNF?), as well level lipid accumulation liver, significantly higher HFD-fed APOB-100 males compared females. However, almost completely abolished hyperlipidemic animals. expression thermogenesis marker, uncoupling protein-1 (Ucp1), was subcutaneous white tissue healthy females, brown males. Lipidomic analyses revealed that hyperlipidemia essentially remodeled lipidome tissue, affecting both membrane storage fractions, which partially restored sexes. Our results more severe metabolic disturbances efficiently reduced body weight, levels, pro-inflammatory factors, hepatic our model.